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Woman suffers for years before condition diagnosed

Tuyet Le stands with her daughter, Kimberly Ho. (Courtesy of the Ho Family)

Kimberly Ho, a newly minted nurse at Children’s National Medical Center just off a 12-hour overnight shift, struggled to focus on a presentation about working with sexually traumatized children and adolescents.

As the picture of a skin infection flashed on the screen, the 22-year-old snapped to attention.

The instructor was recounting the story of a teenage patient who had been given an incorrect diagnosis by a doctor in training, a breach of hospital protocol that had caused an uproar. The lecture, aimed at new staff members, emphasized the importance of working within the chain of command. The girl’s actual diagnosis was largely beside the point, except to Ho.

“I thought, ‘Whoa, that looks a lot like my mom,’ ” Ho said she remembers thinking as she typed the name of the disease into her phone.

For more than two years, Ho’s mother, Tuyet Le, now 56, had been battling a series of perplexing and painful symptoms, including recurrent genital ulcers similar to those pictured in the slide. Despite various diagnoses, none of the prescribed treatments was effective. Le’s symptoms would flare, then vanish, only to recur weeks or months later.

Ho’s attendance at the September 2017 lecture would prove to be instrumental in diagnosing her mother’s illness.

Her mother’s first symptom, genital ulcers, appeared in July 2015, Ho said, while her parents were vacationing in California.

Ho, then in nursing school at Towson University, said that her mother, who was in considerable pain, overcame her embarrassment and called her older daughter for advice.

Ho suggested her mother try soothing baths, called sitz baths. When they didn’t help, Le consulted a gynecologist in California, who tentatively diagnosed a herpes infection and prescribed acyclovir, an anti-viral drug used to treat outbreaks of herpes, shingles and chicken pox. The drug worked and the ulcers disappeared.

A few months later, Ho said, the genital ulcers recurred, even though Le had been taking acyclovir. A blood test revealed that Le had been infected with herpes simplex virus 1, a common infection that causes cold sores.

Le saw her gynecologist, who performed a biopsy. The results were inconclusive, so the doctor referred Le to a dermatologist. When the ulcers disappeared a few weeks later, Le decided there was no point seeing the specialist.

Several months later, she confronted a new problem: Her right elbow was suddenly swollen and painful. Le, who has worked for more than two decades in a factory that makes airplane parts, struggled to perform her job.

She consulted a rheumatologist who diagnosed her with rheumatoid arthritis, an autoimmune disease that causes painful, swollen joints. After several weeks, the swelling disappeared, but the genital ulcers returned.

In the fall of 2016, six months after the elbow problem had resolved, Le woke up with a badly swollen left ankle. “It looked like it was broken,” Ho recalled.

Her primary care doctor, Huyanh Ton, ordered blood tests. Two markers that signal inflammation, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were elevated and considerably higher than those seen in people with rheumatoid arthritis.

Because high levels can indicate a serious disorder, including some forms of cancer, Ton referred her to a hematologist.

The hematologist said he wasn’t sure what was wrong. Ho said he recommended a hip bone biopsy and ordered “a ton of labs,” mostly specialized blood and urine tests. Le refused the bone biopsy; the blood and urine tests showed nothing unusual. By now, she was battling a new problem that made her especially miserable: oral ulcers pocked her tongue and the inside of her mouth.

Ho said her mother’s episodic, debilitating illness was taking a toll on the family. She often ducked out of class to call doctors, while her normally active mother grew depressed, worried about her health and the family’s mounting medical bills.

“She was kind of freaking out,” Ho recalled. “She kept asking, ‘Do I have cancer?’ ”

“All the time I was watching her suffer, no one could tell me what was going on,” Ho said.

A passing reference in a class would change that. The case, Ho recalled, involved a teenager who had been told by a resident that she had genital herpes.

“The family freaked out and asked how she got it,” Ho said.

After a work-up, the girl’s ulcers were found to be a symptom not of herpes but of a rare disorder known as Behcet’s syndrome or Behcet’s disease. The chronic disorder causes inflammation in blood vessels in various parts of the body. Attacks flare, then subside. Oral and genital sores are among the most common symptoms. Without treatment, inflammation can worsen causing blindness, a stroke or, rarely, death.

The similarity of her mother’s symptoms, their episodic nature and the fact that Behcet’s is common in parts of Asia bolstered Ho’s suspicion.

Several months later, during another flare, Le returned to Ton, who had concluded that Behcet’s sounded likely. He prescribed prednisone, a corticosteroid that is a mainstay treatment for the disease.

Le saw a specialist in May 2018. The doctor diagnosed Behcet’s and tweaked Le’s medication regimen. In the past year, Ho said, her mother’s health has improved and she had not suffered a flare.

“It was a long and frustrating process,” Ho said of her mother’s search for a diagnosis.

Le said she is “so thankful that my daughter is a nurse and was able to attend class at the hospital that day.”

Ho said that her mother’s case has made her more sensitive to some of the obstacles her patients may face.