1910 population: 11,020
2010 population: 545,852
Albuquerque’s warm, dry air attracted eastern tuberculosis sufferers like Carrie Tingley, who arrived with her husband Clyde in 1911. Dr. William Lovelace also moved here because of his tuberculosis and began the small, private-practice Lovelace Clinic in 1916 that today is health care giant Lovelace Health Systems.
Route 66 arrived in 1926, but its original path through the city went north-south, along Highway 85, what was then Fourth Street, says Janet Saiers of the Albuquerque Historical Society.
The route was streamlined east-west to Central Avenue in 1937.
During World War II, construction of Kirtland Air Force Base brought people from all across the country, as did a growing University of New Mexico, established during the territorial period.
The addition of Sandia National Laboratories, an offshoot of Los Alamos National Laboratory, was the last in a string of developments making Albuquerque a center of technological advances.
Nevertheless, fatefully, in the 1970s, Bill Gates founded Microsoft in Albuquerque, only to move to the Seattle area in 1979.