After Xavier Hall’s 1-yard touchdown run gave New Mexico State (1-8) a 28-7 lead with 9:23 left in the first half, the Ragin’ Cajuns rattled off 35 unanswered points, including four of Harris’ five TDs, and took a 14-point lead just over four minutes into the fourth quarter.
The Aggies ended an 18-game losing streak last week with a win over transitional Football Championship Subdivision program Abilene Christian. But they have not defeated a Football Bowl Subdivision opponent since a 48-45 victory in Las Cruces over Fresno State on Nov. 12, 2011.
Andrew McDonald, who completed 24 of 34 passes for 327 yards, threw his third touchdown pass of the day when he found Austin Franklin for a 7-yard score with 2:23 remaining, cutting the Louisiana-Lafayette (6-2, 3-0 Sun Belt Conference) lead to 42-35.
Harris, however, put the game on ice with his fifth touchdown, on a 30-yard run, about a minute and a half later.
Franklin finished with 13 catches for 140 yards, both career highs, and two touchdowns.
As four-touchdown underdogs, the Aggies nonetheless controlled the first half, racking up 317 yards of total offense in the first half, while allowing Louisiana just 174 yards of total offense.
New Mexico State still withstood a Louisiana second-have surge to carry a 28-27 lead into the fourth period.
Freshman cornerback Thomas Warren led the Aggies with a career-high 11 tackles.